|
rs28934571
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We suggest that p.R249S may contribute to hepatocarcinogenesis through interaction with HBx, conferring a subtle growth advantage at early steps of the transformation process, but that this interaction is not required for progression to advanced HCC.
|
20538734 |
2010 |
|
rs28934571
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We report here that p53-deficient hepatoma cells (Hep3B) transfected with mutant p53-249ser (codon 249 Arg-->Ser) acquire a new phenotype with an increased in vitro survival and mitotic activity.
|
8174105 |
1994 |
|
rs28934571
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We have analyzed the associations between 19 SNPs spanning the TP53 locus and a single specific aflatoxin-induced TP53 mutation (R249S) in 85 in hepatocellular carcinoma cases and 132 controls from Thailand.
|
23836507 |
2013 |
|
rs28934571
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We discovered that the TP53 R249S mutation occurred in 7.7% of the HCC patients, and it was significantly associated with poor diagnosis.
|
28412734 |
2017 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two single nucleotide polymorphisms (SNPs) in the gene loci of p53 pathway, p53 codon 72 Arg72Pro and MDM2 SNP309 (T > G), have been shown to cause perturbation of p53 function, but the effect of the two SNPs on the risk of hepatocellular carcinoma (HCC) remains inconsistent.
|
23292895 |
2013 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two single nucleotide polymorphisms (SNPs) in the gene loci of p53 pathway, p53 codon 72 Arg72Pro and MDM2 SNP309 (T > G), have been shown to cause perturbation of p53 function, but the effect of the two SNPs on the risk of hepatocellular carcinoma (HCC) remains inconsistent.
|
23292895 |
2013 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two single nucleotide polymorphisms (SNPs) in the gene loci of p53 pathway, p53 codon 72 Arg72Pro and MDM2 SNP309 (T > G), have been shown to cause perturbation of p53 function, but the effect of the two SNPs on the risk of hepatocellular carcinoma (HCC) remains inconsistent.
|
23292895 |
2013 |
|
rs121912654
|
|
|
0.720 |
GeneticVariation |
BEFREE |
TP53 mutations, particularly the hot spot mutations R249S and V157F, are associated with poor prognosis for patients with HCC.
|
21616106 |
2011 |
|
rs121912654
|
|
|
0.720 |
GeneticVariation |
BEFREE |
TP53 mutations, particularly the hot spot mutations R249S and V157F, are associated with poor prognosis for patients with HCC.
|
21094160 |
2011 |
|
rs28934571
|
|
|
0.800 |
GeneticVariation |
BEFREE |
TP53 mutations, particularly the hot spot mutations R249S and V157F, are associated with poor prognosis for patients with HCC.
|
21616106 |
2011 |
|
rs28934571
|
|
|
0.800 |
GeneticVariation |
BEFREE |
TP53 mutations, particularly the hot spot mutations R249S and V157F, are associated with poor prognosis for patients with HCC.
|
21094160 |
2011 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, MDM2 SNP 309 and p53 Arg72Pro are associated with the early development of HCC in Korean patients with chronic HBV infection.
|
18390844 |
2008 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, MDM2 SNP 309 and p53 Arg72Pro are associated with the early development of HCC in Korean patients with chronic HBV infection.
|
18390844 |
2008 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, MDM2 SNP 309 and p53 Arg72Pro are associated with the early development of HCC in Korean patients with chronic HBV infection.
|
18390844 |
2008 |
|
rs28934571
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Thus, R249S may specifically cooperate with HBX in a pathway to HCC</span> that bypasses cirrhosis.
|
23200676 |
2013 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study aimed to assess whether polymorphisms in the single-nucleotide polymorphism miR-34b/c T>C (rs4938723) and TP53 Arg72Pro (rs1042522) increase the risk of HCC and influence outcome in patients with HCC.
|
23632240 |
2013 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study aimed to assess whether polymorphisms in the single-nucleotide polymorphism miR-34b/c T>C (rs4938723) and TP53 Arg72Pro (rs1042522) increase the risk of HCC and influence outcome in patients with HCC.
|
23632240 |
2013 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study aimed to assess whether polymorphisms in the single-nucleotide polymorphism miR-34b/c T>C (rs4938723) and TP53 Arg72Pro (rs1042522) increase the risk of HCC and influence outcome in patients with HCC.
|
23632240 |
2013 |
|
rs28934571
|
|
|
0.800 |
GeneticVariation |
BEFREE |
This review will discuss these findings as well as their clinical significance and implications for the development of a strategy to target multiple molecules as a therapy for p53-R249S-harboring HCC.
|
30608603 |
2019 |
|
rs28934571
|
|
|
0.800 |
GeneticVariation |
BEFREE |
These findings suggest that in HCC from The Gambia, complete HBX sequences are often associated with the presence of TP53 R249S mutation.
|
22759751 |
2012 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no evidence for any association with early age of HCC onset when deleterious alleles of MDM2 SNP309 and TP53 Arg72Pro where present.
|
22180176 |
2012 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no evidence for any association with early age of HCC onset when deleterious alleles of MDM2 SNP309 and TP53 Arg72Pro where present.
|
22180176 |
2012 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no evidence for any association with early age of HCC onset when deleterious alleles of MDM2 SNP309 and TP53 Arg72Pro where present.
|
22180176 |
2012 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The study on p53 Arg72Pro and XRCC1 Arg399Gln polymorphism in HCC patients demonstrated differences in allele frequencies compared to their controls.
|
23053887 |
2013 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The study on p53 Arg72Pro and XRCC1 Arg399Gln polymorphism in HCC patients demonstrated differences in allele frequencies compared to their controls.
|
23053887 |
2013 |